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KMID : 0895820110210040041
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Journal of Oriental Rehabilitation Medicine
2011 Volume.21 No. 4 p.41 ~ p.47
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Single Oral Dose Toxicity of TB001 in Rats
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Cha Yun-Yeop
Sun Seung-Ho
Park Won-Hyung
Park Dong-Sik
Kim Jae-Hyun
Kim Hee-Yeon
Lim Sang-Hyun
Kim Kyung-Hee
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Abstract
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Objectives: This study was performed to investigate single oral dose toxicity of TB001, the extract mixture of Purple loosestrife and Aceriphyllum rossii.
Methods: The mortality, general symptom, change of weight, and necropsy findings was investigated for 14 days after a dose(2000 mg/kg B.W.) of TB001 was given, using SD rats of both male and female according to “The guideline of toxicity test for medicine and others”.
Results: The death of rats and abnormal finding was not observed. There was no the significant difference of weight between control group and TB001 group.
Conclusions: The abnormalities at the necropsy finding of all survived rats was not detected. The study suggested that there is no toxicity in single dose(2000 mg/kg B.W.) of TB001.
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KEYWORD
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TB001, Single oral dose toxicity, Purple loosestrife, Aceriphyllum rossii
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